At this point, Masseria started demanding a share of Reina's criminal profits, prompting Reina to consider changing allegiance to Maranzano.
When Masseria learned of Reina's possible betrayal, he plotted with Reina lieutenant Tommy Gagliano to kill him.
There would be 24 organizations (to be known as "families") throughout the country who would elect their own bosses.
Maranzano also reorganized all the Italian-American gangs in New York City into five families to be headed by Maranzano, Lucky Luciano, Vincent Mangano, Tommy Gagliano and Joseph Profaci.
When Maranzano learned about Luciano's disaffection, he hired a gunman to kill him. Several Jewish assassins provided by Luciano associate Meyer Lansky murdered Maranzano in his office.
Luciano now became the most powerful mobster in New York.
The next boss was Tommy Lucchese who served as Gagliano's underboss for over 20 years, who turned the family around to become one of the most powerful families to sit on the Commission.
Casso also had authority over NYPD detectives Louis Eppolito and Stephen Caracappa, both carried out at least 8 murders for him.
Amuso later promoted one of his longtime partners, Anthony Casso to underboss.
They instituted one of the bloodiest reigns in Mafia history, ordering virtually anyone who crossed them to be murdered.
During the early 1920s, Reina became a powerful prohibition era boss and aligned himself with Joseph Masseria, the most powerful Italian-American crime boss in New York.
Masseria soon became involved in the Castellammarese War, a vicious gang war with a rival Sicilian boss Salvatore Maranzano.
As the family's leader, Reina avoided the Mafia-Cammora War for control over New York City.