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Molaison also showed signs of retrograde amnesia spanning a period of about 3 years prior to the surgery suggesting that recently acquired memories of as long as a couple years could remain in the MTL prior to consolidation into other brain areas.Research into other patients with resections of the MTL have shown a positive relationship between the degree of memory impairment and the extent of MTL removal which points to a temporal gradient in the consolidating nature of the MTL.After Molaison underwent a bilateral medial temporal lobe resection to alleviate epileptic symptoms the patient began to suffer from memory impairments.Molaison lost the ability to encode and consolidate newly learned information leading researchers to conclude the medial temporal lobe (MTL) was an important structure involved in this process.and occurs within the first few hours after learning, and systems consolidation, where hippocampus-dependent memories become independent of the hippocampus over a period of weeks to years.Recently, a third process has become the focus of research, reconsolidation, in which previously-consolidated memories can be made labile again through reactivation of the memory trace.In recent decades, advancements in cellular preparations, molecular biology, and neurogenetics have revolutionized the study of consolidation.

is one form of memory consolidation seen across all species and long-term memory tasks.Long-term memory, when discussed in the context of synaptic consolidation, is memory that lasts for at least 24 hours.An exception to this 24-hour rule is long-term potentiation, or LTP, a model of synaptic plasticity related to learning, in which an hour is thought to be sufficient.The two proposed the perseveration-consolidation hypothesis after they found that new information learned could disrupt information previously learnt if not enough time had passed to allow the old information to be consolidated.Systematic studies of anterograde amnesia started to emerge in the 1960s and 1970s.

and consolidating the-24and consolidating the-20and consolidating the-11

Synaptic consolidation is achieved faster than systems consolidation, within only minutes to hours of learning in goldfish.

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